Florid Cirrhosis: A Review of 35 Cases

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Abstract
Clinical, laboratory and morphologic findings and morphologic differential diagnoses of 35 cases of a chronic toxic hepatitis are given. The characteristic features are: history of alcoholism and malnutrition, severe hepatocellular degeneration and necrosis, patchy fatty metamorphosis, cholangiolitis and formation of many thin connective tissue membranes. These membranes condense in places to septums and in few places cirrhotic formation is noted in the form of regenerative nodules and portohepatic venous anastomoses. The lesion is regarded as hepatocellular degeneration in a nutritional fatty liver possibly ushered in by intercurrent infections, the fat being lost during the terminal disease. Since the lesion represents a rapidly progressing transition into cirrhosis, although the extent of cirrhosis is still minimal, the term florid cirrhosis is proposed. This picture can also be seen in biopsy specimens of patients not succumbing to the disease. The lesion is regarded as a link between fatty liver and cirrhosis.