Radiation Studies on the Hemolysin of Newcastle Disease Virus

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Abstract
A study was undertaken to determine the size and number of the molecules associated with the hemolytic property. The fact that the hemolysin and hemagglutinin have separate identities is suggested by the radiation data to be discussed, and by the fact that Granoff, Liu and Henle have shown that the small hemagglutinin of Newcastle disease virus (NDV) does not possess the hemolytic property. Ionizing radiation studies on the NDV hemolysin indicate that this property resides in about 15 independent targets. If we assume that these hemolysin molecules are flat plates, they will be 100-140 A in radius and 20 A thick. Fifteen molecules of this dimension arranged on the virus surface would cover 15 to 30% of the total surface area.

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