Detection of Metastases in the Skeleton with Radioactive Colloidal Gold

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Abstract
Radioactive colloidal gold (198Au) is rapidly removed from the blood, following intravenous injection, by the reticuloendothelial system. Most of the injected colloid is taken up by the liver, but a small part (about one tenth) is taken up by the bone marrow. This permits the obtaining of a scintigram of areas rich in isotope such as bone marrow; in those where the metastatic foci are present, a lacular picture is seen in a very early phase, before the tumor proliferation has caused alterations of the bone structure. The tracer''s intense fixation in the liver does not permit the obtaining of clear images from the central part of the body and the authors have concentrated on the pelvis, an area rich in bone marrow, where metastatic invasion is frequent.

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