Dosimetry of iodine-123 iomazenil in humans
- 1 July 1993
- journal article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 20 (7) , 580-584
- https://doi.org/10.1007/bf00176551
Abstract
The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq.Keywords
This publication has 13 references indexed in Scilit:
- Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECTNuclear Medicine Communications, 1993
- Benzodiazepine receptors and cerebral blood flow in partial epilepsyEuropean Journal of Nuclear Medicine and Molecular Imaging, 1991
- The story and activity of flumazenil (Anexate).1989
- IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCIThe Lancet, 1988
- Regional Specific Binding of [11C]RO 15 1788 to Central Type Benzodiazepine Receptors in Human Brain: Quantitative Evaluation by PETJournal of Cerebral Blood Flow & Metabolism, 1988
- Population Radiation Absorbed Dose From Nuclear Medicine Procedures in the NetherlandsHealth Physics, 1988
- Population Characteristics and Absorbed Dose to the Population From Nuclear MedicineHealth Physics, 1986
- Effective dose equivalent from radiopharmaceuticalsEuropean Journal of Nuclear Medicine and Molecular Imaging, 1984
- Use of ionizing radiation and radionuclides on human beings for medical research, training, and nonmedical purposes. Report of a WHO Expert Committee.1977
- Dose to the Fetus from Radionuclides in the BladderHealth Physics, 1973