INFLUENCES OF γ-AMINOBUTYRIC ACID AND SUBSTANCES POSSESSING SIMILAR CHEMICAL STRUCTURE ON HEXOKINASE OF THE BRAIN AND HEART MUSCLE

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Abstract
Hexokinase activity of the homogenate of rabbit cerebral cortex was accelerated by 0.025 M n-butyramine, gamma-aminobutyrate, but inhibited by N-acetyl-gamma-aminobutyrate. That of heart muscle was markedly increased by the addition of 6 -amino-n-valerate, gamma-aminobutyrate, considerably by n-butyramine, and strongly suppressed by N-acetyl-gamma-aminobutyrate. B-alanine, gamma-amino-a-and gamma-amino-B-hydroxybutyrates gave no significant effect. The NH2(CH2)3- group is likely the site of activating effect.