EOSINOPHILIC GRANULOMA

1 June 1950

journal article
research article
Published by American Medical Association (AMA) in Archives of Dermatology and Syphilology

Vol. 61 (6) , 957-970
https://doi.org/10.1001/archderm.1950.01530130075014

Abstract

THE TERM "eosinophilic granuloma" usually refers to a specific bone lesion considered by some (particularly Jaffe and Lichtenstein¹) to be the early monosymptomatic form of Hand-Schüller-Christian disease. This concept is well supported by Holm, Teilum and Christensen's²report of 6 cases showing a gradual transition from the early solitary lesion to the picture of Hand-Schüller-Christian disease. However the term "eosinophilic granuloma" has not been confined to this entity. It has been applied to other conditions, apparently different from Hand-Schüller-Christian disease. Curtis and Cawley³reported the case of a girl whose condition was similar to a seborrheic dermatitis with small, red, discrete and coalescent papules on the buttocks and eroded patches in the mouth. In each axilla weeping, sharply demarcated erythematous papules were noted. Roentgenologic examination showed destructive lesions of a rib and the ilium. Biopsy specimens of the lesions of the skin

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