Comparative Effectiveness of Two Penicillin Treatment Schedules in Pneumococcal Infections of Mice
- 1 March 1948
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 67 (3) , 278-280
- https://doi.org/10.3181/00379727-67-16275
Abstract
Therapeutic effects of penicillin injd. every 12 hrs. into mice infected with pneumococci intraperit. were compared with the effects of similar daily doses divided into 8 injns. at intervals of 3 hrs. With both treatment schedules, the 100% curative daily dose and the PD5o daily dose were found to be similar. Under the conditions of the expt., the effectiveness of penicillin appeared to depend more upon the total daily dose of the drug than upon the intervals at which it was adm.Keywords
This publication has 3 references indexed in Scilit:
- Therapeutic Effectiveness of Single Oral Doses of PenicillinExperimental Biology and Medicine, 1946
- DYNAMICS OF THE ACTION OF PENICILLIN IN EXPERIMENTAL ANIMALSArchives of internal medicine (1960), 1946
- THE ABSORPTION, EXCRETION, AND DISTRIBUTION OF PENICILLIN 1Journal of Clinical Investigation, 1943