Water‐soluble fullerene derivatives attenuate exsanguination‐induced bronchoconstriction of guinea‐pigs

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Abstract
1 This study investigated the effects of increased antioxidants (administration of water‐soluble fullerenol‐1 and pre‐exposure to chronic hypoxia) as well as an iron‐chelating agent (deferoxamine) on exsanguination‐induced noncholinergic airway constriction in guinea‐pigs. 2 Fullerenol‐1 usually did not cause significant alteration in respiratory function (lung volumes, dynamic respiratory compliance, maximal expiratory flow at 50% total lung capacity (V¨max50), and forced expiratory flow at 0.1 s (FEV0.1)) at low (200 μg kg−1) or at high doses (2 mg kg−1), except that it produced a slight bronchial constricting action (decreases in both V¨max50 and FEV0.1) at high doses (2 mg kg−1) via intratracheal instillation. 3 Beginning 15 min after exsanguination, there was a marked temporal decrease in FEV0.1, indicating a gradual increase in airway constriction with time. 4 Administration of either fullerenol‐1 or deferoxamine, or pre‐exposure to chronic hypoxia significantly ameliorated the exsanguination‐induced bronchoconstriction. The results provide evidence that oxygen radicals play an important role in exsanguination‐induced airway constriction. 5 The significant effects of the increased antioxidants and deferoxamine, however, cannot be explained by the alteration in either tracheal neutral endopeptidase activity or lung tissue substance P level.

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