Atmospheric Pollutants and the Pathogenesis

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Abstract
Influenza-infected mice exposed continuously to 20 ppm of sulfur dioxide (SO2) for seven days after virus exposure developed more pneumonia than virus control mice. Dose-response experiments suggested that the post virus SO2-induced increase in influenzal pneumonia began at about 7 to 10 ppm. The increase in pneumonia was not influenced by altering the virus dosage within a 5 to 100 mouse infectious dose range. A similar increase (15% to 20%) in influenzal pneumonia was observed when mice were exposed to 25 ppm of SO2 prior to initiation of virus infection. The SO2 exposure had no effect on the growth of influenza virus in the lungs of mice. Rather, the increase in She amount of pneumonia was associated with SO2 concentrations which induced low-grade, inflammatory lesions in the lung.

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