Molecular cytogenetic analysis of a complex t(10;22;11) translocation in ewing's sarcoma
- 1 March 1992
- journal article
- case report
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 4 (2) , 188-191
- https://doi.org/10.1002/gcc.2870040214
Abstract
Fluorescence in situ hybridization (FISH) using chromosome-specific plasmid libraries and chromosome region-specific DNA markers allowed the characterization of a t(10;22;11) (p11.2;q12;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of ES, especially for determining the localization of the translocated 11q24-25 segment in complex or variant translocations.Keywords
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