Control of In Vivo Contraction/Relaxation Kinetics by Myosin Binding Protein C
Open Access
- 20 November 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 116 (21) , 2399-2408
- https://doi.org/10.1161/circulationaha.107.706523
Abstract
Background— Cardiac myosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by protein kinase A (PKA) regulates cross-bridge formation and kinetics in isolated myocardium. We tested the influence of cMyBP-C and its PKA-phosphorylation on contraction/relaxation kinetics in intact hearts and revealed its essential role in several classic properties of cardiac function.Keywords
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