Reproducible Oral Infection Rates in Monkeys with the Mahoney Strain (Type 1) of Poliomyelitis Virus.

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Abstract
Virus was given by stomach tube to cynomolgus monkeys after a 48-hr. fasting period. A single dose of 5 ml. of 10% virus suspension in 25 ml. of milk produced paralysis in one out of 5 monkeys; 3 doses of 5% virus given in 25 ml. of milk on the same day produced paralysis in 2 out of 4 monkeys, and 3 doses in 5 ml. of 2.5% virus in 25 ml. of milk given the same day produced paralysis in 2 out of 4 monkeys. Alkalinizing the stomach with either NaHCO3 or Al(OH)3 failed to affect the infection rate using a single dose of 5 ml. of 20% virus in 25 ml. of milk. Using 5 ml. of 20% virus in 25 ml. of cream (12% fat content) and given in a single dose, produced paralysis in 6 out of 10 monkeys. Using 5 ml. of 20% virus mixed with table cream (18% fat content) or whipping cream (33% fat content) and given in a single dose failed to increase the infection rate. In 5 separate chemoprophylactic expts., a total of 50 control monkeys received 5 ml. of 20% virus in cream (12% fat content) in a single dose and 26 of them developed paralysis. A uniform paralytic rate of 56% was thus obtained.

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