Safety, Efficacy, and Effectiveness of Live, Attenuated, Cold‐Adapted Influenza Vaccine in an Indicated Population Aged 5–49 Years

Abstract
Background. Three important studies have supported licensure of live, attenuated, cold-adapted influenza vaccine (CAIV-T [FluMist; MedImmune Vaccines]): (1) a pediatric efficacy trial involving children 15–71 months of age, (2) a large safety study of medically attended events occurring among children 1–17 years of age, and (3) an effectiveness trial involving healthy working adults 18–64 years of age.