The Effect of Chemotherapy on the Duration of the Carrier State Following Scarlet Fever

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Abstract
THE utilization of chemoprophylaxis in the control of infections spread by the respiratory tract is a recent development that is gaining ever wider application. In 1939 it was shown that sulfanilamide was effective in preventing streptococcal upper respiratory infections and relapses in rheumatic fever.1 2 3 Kuhns et al.4 found that sulfadiazine, when given prophylactically, diminished meningococcal carrier rates as well as the incidence of meningococcal meningitis. During the course of a scarlet-fever epidemic in a United States naval station, the routine administration of prophylactic doses of sulfadiazine to healthy contacts appeared to be effective in checking its spread.5 Conflicting reports have . . .