THE EFFECT OF PULMONARY VENTILATION ON THE PRESSOR ACTION OF ADRENALINE

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Abstract
In spinal cats, variation in pulmonary ventilation alters markedly the pressor action of small doses of adrenaline. With both hypo- and hyperventilation, the rises of blood pressure induced by adrenaline are smaller than when ventilation is normal. Bleeding, histamine, adrenalectomy, damage of the spinal cord or bilateral removal of the sympathetic chain, result also in reduction of the sensitivity of the preparation to small doses of adrenaline. Prolonged hyperventilation or destruction of the spinal cord abolishes the effects of changes in ventilation on the action of the small doses of adrenaline.

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