Citrulline for Reye's Syndrome

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Abstract
To the Editor: Several investigators have attributed the encephalopathy of Reye's syndrome to severe hyperammonemia. Therapies such as neomycin, peritoneal dialysis, and exchange transfusion, have been used to reduce hyperammonemia (and possibly to remove other unidentified toxins). Recent studies of amino acid derangements accompanying the disease suggest another possible measure —the administration of citrulline — to reduce the hyperammonemia. Shih (unpublished data), Kang,1 and Hilty et al.2 have observed a consistent and specific blood amino acid profile in Reye's syndrome, characterized by high levels of glutamate, glutamine, alanine, and lysine, by low levels of arginine, and by very low or . . .

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