STUDIES ON THE HISTOGENESIS OF EXPERIMENTAL GRANULOSA CELL TUMOURS IN RATS

Publisher Website
Google Scholar
Abstract
Isolated groups of granulosa cells, corpus luteum cells, interstitial cells or isolated small follicles were autotransplanted below the capsule of the spleen or to the anterior chamber of the eye of spayed rats. At the time of operation, the animals were 2 months old. Some grafts were studied after 8 weeks, others after 1 year. Corpus luteum cells and granulosa cells grew but slightly or were absorbed and produced no tumors. Interstitial cells sometimes grew on transplantation to the anterior chamber of the eye or to the spleen. After 2 months, luteomas developed and after 1 year tumors of a granulosa cell type had formed in the spleen as well as in the eye. Most of the follicles grew. They became luteinized and the ova degenerated. The surrounding theca proliferated and became luteinized. Granulosa cell tumors usually developed within 1 year after insertion of the graft. It is concluded that experimental granulosa cell tumors in rats may originate from theca or interstitial cells. They can be produced by transplanting single follicles or small groups of interstitial cells to the anterior eye chambers as well as to the spleen in spayed animals.

This publication has 0 references indexed in Scilit: