Perturbation of Respiration in Candida utilis: Induction of Metabolic Oscillations

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Abstract
The effects of potentially perturbating influences on the respiration of glucose-grown C. utilis were studied using an open O2 electrode system. Periods of anaerobiosis as short as 2 min produced an oscillation in respiration after the air supply was restored. Longer exposure to anoxia was followed by an overshoot in dissolved O2 after switching back to a gas phase of air. Centrifugation, cold shock or nutrient starvation caused less disturbance to respiration rates than did anaerobic-aerobic transitions are contrasted with the slow cell cycle-dependent oscillations previously observed in synchronous cultures.