MULTIPLE-MYELOMA AMONG ATOMIC-BOMB SURVIVORS IN HIROSHIMA AND NAGASAKI, 1950-76 - RELATIONSHIP TO RADIATION-DOSE ABSORBED BY MARROW

  • 1 January 1982
    • journal article
    • research article
    • Vol. 69  (2) , 323-328
Abstract
The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From Oct. 1950 to Dec. 1976, 29 cases of multiple myeloma were confirmed in this sample. The standardized relative risk (RR) adjusted for city, sex and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 yr. The estimated risk in these individuals is .apprx. 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 yr or more after exposure.