CYTOCHALASIN-B REVERSIBLY INCREASES OUTFLOW FACILITY IN EYE OF CYNOMOLGUS MONKEY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (1) , 47-53
Abstract
In cynomolgus monkeys [Macaca fascicularis] intracameral infusion of 0.2-5.0 .mu.g of cytochalasin B caused an increase in outflow facility, as measured by 2-level constant pressure perfusion. Cytochalasin B had its full effect in eyes which had undergone surgical disinsertion of the ciliary muscle from the scleral spur, and were therefore insensitive to pilocarpine. The cytochalasin effect was apparent in less than 20 min and was largely reversible over a few hours. Thirty to 50 days after the infusion, facility was normal, and a 2nd reaction could be elicited. No early or late damage to anterior segment structures was apparent by routine biomicroscopy during or after the single administration.

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