COMPARATIVE ANTIPROLIFERATIVE ACTIVITY INVITRO OF NATURAL INTERFERON-ALPHA AND INTERFERON-BETA FOR DIPLOID AND TRANSFORMED HUMAN-CELLS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (12) , 4948-4953
Abstract
The relative antiproliferative activity of natural interferons .alpha. and .beta. was compared in 43 in vitro assays of 25 human cell lines or strains. After 120 h of continuous exposure to 100 units/ml, interferon .beta. produced > 20% growth inhibition in 22 cells (88%), and interferon .alpha. produced 20% growth inhibition in 9 cells (36%). Only Daudi (Burkitt''s lymphoma) cells were consistently more inhibited by interferon .alpha.. In the other 24 human cells, the effect of interferon .beta. was greater or equal to interferon .alpha.. Although no tissue specificity for interferon .beta. was evident, interferon .alpha. generally had greater antiproliferative effects in cells of hematopoietic origin. The effect of interferon .alpha. was usually established by 72 h with little further growth inhibition at 120 h. Conversely, interferon .beta. often had a greater antiproliferative effect at 120 than at 72 h. These findings support the hypothesis that various interferons may differ in their biological, cell-regulatory, and clinical effects.

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