CROSSREACTIVITY BETWEEN QA-1 REGION AND H-2K ANTIGENS

Publisher Website
Google Scholar
Abstract
Antiserum (A.TL .times. A.SW)F1 anti-A.TH is specific for the products of the Qa-1a region. It reacts only weakly or, under certain circumstances, not at all with the immunizing cells, but it reacts strongly with 100% of H-2f and H-2p [mouse] lymhphocytes. The molecules that are the target of this strong heteroclitic reactivity are controlled by a gene in the K region, most likely the K locus itself. The results are interpreted in terms of crossreactivity of Qa-1-specific antibodies with class I major histocompatibility complex molecules. This crossreactivity underscores the relatedness of Qa and class I loci and strengthens the argument that Qa loci are members of the class I family.

This publication has 2 references indexed in Scilit: