Cell Surface Immunoglobulin. XIV. Synthesis, Surface Expression, and Secretion of Immunoglobulin by Peyer's Patch Cells in the Mouse

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Abstract
Peyer's patches (PP)5 have characteristics distinguishing them from both central and peripheral lymphoid tissues. In contrast to central lymphoid tissue, PP are antigen-dependent for their development (1, 2); they contain T as well as B cells (3, 4), and the mitotic rate of their cells is too low for them to be a major source of peripheral B cells during ontogeny (5). Nevertheless, PP also differ from typical peripheral lymphoid tissues in several respects: PP are adjacent to specialized portions of intestinal epithelium (6); they contain few plasma cells (7, 8); they do not make antibody in vivo unless antigen is introduced directly into their parenchyma (9, 10); and they are comparatively rich, in common with other gut-associated lymphoid tissues (4, 11–13), in lymphoid cells bearing surface IgA. Immunoglobulins produced by PP cells are of interest because of these unusual characteristics and because of the proposed role of the PP as a major source of precursors of IgA-secreting plasma cells (11, 14).

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