Metabolic products of microorganisms. 243. Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger.
- 1 January 1988
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 41 (5) , 595-601
- https://doi.org/10.7164/antibiotics.41.595
Abstract
Pyridazomycin (1), a new antifungal antibiotic produced by Streptomyces violaceoniger sp. griseofuscus (strain Tu 2557), was detected in a selective screening against Mucor hiemalis (Tu 179/180). The amino acid side chain of 1 can be seen as L-ornithine, whose .gamma.-nitrogen atom is part of a pyridazine ring building a quaternary ammonium system. The structure of 1 was established by spectroscopic analysis of the parent compound and degradation products. The occurrence of a pyridazine ring in microbial secondary metabolites is unique.This publication has 0 references indexed in Scilit: