URINARY COLLAGEN CROSSLINKS REFLECT THE RADIOGRAPHIC SEVERITY OF KNEE OSTEOARTHRITIS
- 1 November 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 31 (11) , 759-761
- https://doi.org/10.1093/rheumatology/31.11.759
Abstract
The collagen crosslinks deoxypyridinoline and pyridinoline are indices of mature collagen breakdown and reflect increased bone turnover. Urinary levels were found to be significantly raised in a group of 59 women with knee OA com pared to 110 female controls from the general population. Levels of the crosslinks correlated significantly with X-ray grade of all subjects including women from the general population with mild, often asymptomatic, disease. These correlations were not diminished after adjustment for age and weight.Keywords
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