Alleles of the rat T-cell receptor ? chain gene complex

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Abstract
Inbred rat strains provide a rich source of genetic diversity in immunologically relevant gense. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor Cβ1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3′ to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing Vβ, Dβ, and Jβ elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.

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