Effect of Bromoergocriptine on TRH-Induced Growth Hormone and Prolactin Release in Acromegalic Patients

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Abstract
In an attempt to evaluate the dynamics of growth hormone (GH) and prolactin secretion in acromegalic patients the response of serum GH as well as prolactin to 2-bromo-.alpha.-ergocriptine (CB154) alone or to CB154 combined with thyrotropin-releasing hormone (TRH) was studied in 8 subjects with this disease. Oral administration of CB154 unequivocally decreased serum prolactin levels in all 8 patients; GH-inhibitory action of the drug was observed only in 6 subjects who responded to TRH with secretion of GH. The response of serum GH to TRH was not qualitatively and quantitatively altered by the treatment of patients with CB154 in a daily dose of 5 mg for 2 wk. This treatment remarkably suppressed basal levels of prolactin and completely blocked TRH-induced prolactin release in all subjects. There appears to exist a dissociation between GH and prolactin responses to CB154 in acromegalic patients. CB154 and TRH may not share a common site of action on GH release in this pathologic state.

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