The synthesis of 6,7‐dihydro‐5H‐pyrrolo[3,4‐d]pyrimidines. II. 4‐Hydroxy, 4‐mercapto, 2‐amino‐4‐hydroxy and 2,4‐dihydroxy derivatives
- 1 March 1967
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 4 (1) , 1-7
- https://doi.org/10.1002/jhet.5570040101
Abstract
Several new types of compounds in the 6,7‐dihydro‐5H‐pyrrolo[3,4‐d]pyrimidine series have been prepared. Included are a 6‐acyl derivative unsubstituted in the pyrimidine ring, as well as 4‐hydroxy, 4‐mercapto, 2‐amino‐4‐hydroxy and 2,4‐dihydroxy derivatives. These products were derived directly or indirectly from 4‐cyano‐ or 4‐carbethoxy‐1‐acyl‐3‐amino‐3‐pyrroline intermediates. 3‐Hydroxy, 3‐amino, and 3‐thioformylamino‐1‐acyl‐3‐pyrroline‐4‐thiocarboxamides have been obtained and the 3‐thioformylamino derivatives shown to undergo base‐catalyzed cyclization to close a 4‐mercaptopyrimidine ring.Keywords
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