Pyoderma Gangrenosum

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Abstract
To the Editor: Part of the reason why the etiology and pathogenesis of pyoderma gangrenosum have remained a mystery has been the difficulty in examining patients before ulceration. We have recently studied two patients with pyoderma gangrenosum before ulceration with histopathology and immunofluorescence. The first patient had a tender, fluctuant plaque of the chest of five days' duration. Aspiration of the lesion revealed negative growth for bacteria (aerobes and anaerobes), fungi and acid-fast bacilli. A biopsy performed about 2 cm from the center of the plaque showed a dense invasive, destructive infiltrate of the lower and mid-dermis with large and . . .

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