Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

Open Access

1 May 2004

journal article
Published by American Society for Microbiology in Clinical and Vaccine Immunology

Vol. 11 (3) , 621-624
https://doi.org/10.1128/cdli.11.3.621-624.2004

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

Keywords

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