Spectral Suppression with UV-Multichannel Detection in Peak Homogeneity Validation

1 July 1991

journal article
Published by Oxford University Press (OUP) in Journal of Chromatographic Science

Vol. 29 (7) , 298-304
https://doi.org/10.1093/chromsci/29.7.298

Abstract

The theoretical basis of spectral suppression in peak homogeneity validation is reviewed. Past applications of pharmaceutical interest are examined and the controversial area of wavelength optimization illustrated with examples from the work on atenolol and glibenclamide. An outline of the different stages involved in a successful application of the technique is given briefly. The technique was found to be reliable and easy to use.

Keywords

SPECTRAL SUPPRESSION
PEAK HOMOGENEITY
MULTICHANNEL DETECTION
UV MULTICHANNEL
HOMOGENEITY VALIDATION

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