Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins

1 October 1975

journal article
research article
Published by Springer Nature in Nature

Vol. 257 (5529) , 764-767
https://doi.org/10.1038/257764a0

Abstract

RNA transcripts from chromatin of S phase but not G₁ cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G₁ non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.

Keywords

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