Increased growth of RSV-induced tumors in chickens partially tolerant to MHC alloantigens

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Abstract
Chickens withB 2 B 2 MHC genotypes were made partially tolerant to B5 MHC cell-surface antigens and the fate of their Rous-sarcoma-virus (RSV)-induced tumors was determined.B 2 B 2 chickens partially tolerant to viable or lysed white blood cells (WBC) or viable red blood cells (RBC) fromB 5 B 5 chickens had a significantly higher incidence of tumor progression than untreated, PBS-treated, orB 2 B 2 chickens inoculated with WBC from otherB 2 B 2 chickens. The criteria for tolerance were absence of antibody titer to the cell type inoculated and acceptance of allografts fromB 5 B 5 donors byB 2 B 2 chickens. Graft-vs-host reactions occurred only inB 2 B 2 chickens inoculated with viable WBC fromB 5 B 5 chickens. It appears thatB 2 B 2 chickens partially tolerant to B5 antigens failed to mount a successful immune response to RSV-induced tumors partly because a B5 MHC antigen(s) cross-reacted with a tumor associated antigen(s) thereby severely limitingB 2 B 2 host recognition of the tumor as foreign. Since WBC and RBC cell-surface antigens appear to contribute similarly to the effect, theB-F- region of the MHC may be involved.