α-Ketoglutarate Application in Hemodialysis Patients Improves Amino Acid Metabolism
- 1 January 1996
- journal article
- clinical trial
- Published by S. Karger AG in Nephron
- Vol. 74 (2) , 261-265
- https://doi.org/10.1159/000189319
Abstract
In hemodialysis patients, free amino acids and α-ketoacids in plasma were determined by fluorescence HPLC to assess the effect of α-ketoglutarate administration in combination with the phosphate binder calcium carbonate on the amino acid metabolism. During 1 year of therapy in parallel to inorganic phosphate, urea in plasma decreased significantly, histidine, arginine and proline as well as branched chain α-ketoacids, in particular α-ketoisocaproate, a regulator of protein metabolism, increased. Thus, administration of α-ketoglutarate with calcium carbonate effectively improves amino acid metabolism in hemodialysis patients as it decreases hyperphosphatemia.Keywords
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