Inhibitory Effect of Guanfacine, a Central α-Adrenoceptor Agonist, on Prolactin Secretion Stimulated by Insulin-Induced Hypoglycemia

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Abstract
In six normal male volunteers oral administration of an α-receptor agonist, guanfacine (1 mg/q.i.d. for 4 days), had no effect on PRL release induced by 5 mg metoclopramide iv. The same treatment with quanfacine in six other normal subjects significantly reduced PRL secretion stimulated by insulininduced hypoglycemia (P < 0.05). These results suggest that an adrenergic pathway, hypothalamic or extrahypothalamic, might be involved in the inhibitory control of PRL secretion.