PHASE-II AND PHARMACOKINETIC STUDY OF AZIRIDINYLBENZOQUINONE [2,5-DIAZIRIDINYL-3,6-BIS(CARBOETHOXYAMINO)-1,4-BENZOQUINONE, DIAZIQUONE, NSC-182986] IN HIGH-GRADE GLIOMAS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (12) , 6102-6105
Abstract
2,5-Diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone (AZQ; Diaziquone, NSC 182986) is a rationally designed antitumor drug possessing sufficient lipid solubility to allow penetration into the CNS. Patients (31) with high-grade glioma and progressive disease following radiation, with or without previous chemotherapy, were treated with 144 cycles of drug, consisting of 20 mg/m2 given as an i.v. infusion on days 1 and 8 of a 28-day cycle. Responses were measured by serial computer tomography scanning. Of the 28 evaluable patients, 6 (21%) had limited improvement (10-40% reduction in tumor size) on computer tomography scan, 10 (36%) had disease stabilization, and 12 (43%) had progressive disease. The drug was well tolerated clinically, with little acute toxicity. The major toxicity was myelosuppression, which appeared cumulative, using this dose regimen. AZQ was measurable in tumor tissue and tumor cyst fluid in patients on therapy. Plasma samples taken during the period of infusion confirm that .gtoreq. 50% of the total AZQ exposure occurs during the infusion period. AZQ behaves as intended by design and demonstrates activity in this poor-prognosis group of patients.

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