Controlled Comparison of Ketanserin and Nifedipine in Raynaud's Phenomenon

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Abstract
Twenty-eight patients suffering from either primary or secondary Ray naud's phenomenon were treated with nifedipine and ketanserin. Each patient was treated with one of the two drugs administered after an adequate washout period. Furthermore each patient was submitted before and after treatment with each drug to computerized digital thermometry to evaluate the therapeutic response. The data obtained during the intake of the two drugs at zero, five, and twenty-three minutes were compared with thermometry-relevant baseline data at the same periods. Ketanserin proved to be useful in the treatment of Raynaud's phenomenon and statistically significantly superior (a < 0.05) with respect to nifedipine in the thermometric controls and also in the subjective evaluation of the patients (p < 0.02). In this study nifedipine did not show par ticular efficacy. Furthermore only 2 patients had to discontinue treatment with ketanserin, whereas 8 had to discontinue treatment with nifedipine (p < 0.001).