Determination of unbound drug concentration and protein-drug binding fraction in plasma
- 17 June 1999
- journal article
- research article
- Published by Wiley in Biomedical Chromatography
- Vol. 13 (4) , 262-266
- https://doi.org/10.1002/(sici)1099-0801(199906)13:4<262::aid-bmc832>3.0.co;2-2
Abstract
The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein–drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis on the chromatographic method, i.e. high‐performance frontal analysis (HPFA). Copyright © 1999 John Wiley & Sons, Ltd.Keywords
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