Effect of L-Histidine on Human and Rat Jejunal Pyruvate Kinase Activity

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Abstract
L-Histidine was found to be an in vitro activator of both human and rat jejunal pyruvate kinase activity and rat hepatic pyruvate kinase activity. Jejunal and hepatic pyruvate kinase activities were higher in rats fed a histidine-complete diet than a histidine-deficient diet. Feeding groups of rats successively larger doses of oral histidine produced a progressive increase in rat jejunal pyruvate kinase activity. An inverse relationship was seen between the pyruvate kinase activity without histidine added and the percent stimulation with histidine added in vitro.The histidine effect appears to be a ubiquitous one in the rat, since stimulation was observed in each of the seven tissues tested. The broad range of the histidine effect suggests that it may play a fundamental role in the regulation of glycolysis in mammalian systems.

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