Cold Agglutinin Formation in Patients Undergoing Haemodialysis. A Possible Relationship to Dialyser Re‐use

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Abstract
Summary: Cold agglutinin formation in patients undergoing haemodialysis. A possible relationship to dialyser re‐use.Cold agglutinins with anti‐N characteristics were shown to develop in as short a time as four months in patients on home dialysis. It appeared that the development of such antibodies is related to dialyser re‐use. Those who were treated without re‐using their dialyser did not develop these antibodies.Anti‐N may cause early graft failure associated with agglutination in a cold allograft. Moreover, if these antibodies develop in patients on dialysis there may be problems with extracorporeal dialysis and blood transfusion.