Lymphocytopenogenic Lymphocytotoxins

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Abstract
Antilymphocyte antibodies are usually thought of as the active ingredients of heterologous serums used for immunosuppression (horse anti-human lymphocyte serum, for example), but antibodies against lymphocytes occur in other contexts. The most familiar of these is that of isoimmunization brought about by either transfusions or pregnancy. Antilymphocyte isoantibodies, which fail to react with the patient's own lymphocytes, are of clinical importance as causes of transfusion reactions; their value as reagents for tissue typing is inestimable. Less well appreciated is the presence in normal human serum of at least two kinds of cytotoxic antilymphocyte antibodies. The first of these kills sheep . . .