Antimicrobial Activity of Basic Cholane Derivatives Part IX
- 1 January 1990
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 323 (4) , 201-205
- https://doi.org/10.1002/ardp.19903230404
Abstract
Twenty new compounds derived from deoxycholic acid have been synthesized. They contain two basic functions: at C-24 (benzylamino, morpholino, diethanolamino, N,N-diethylethylenediamino, N-methylpiperazino) and at β-C-3 (amino, methylamino, ethylamino, benzylamino). The compounds showed interesting antimicrobial activity, as expressed in terms of the low M.I.C. values (0.9-31-μ/ml) against five Gram(+) and four Gram(−) strains, two fungi and one yeast. The compounds inhibit the production of a fluorescent pigment in Pseudomonas aeruginosa: this result suggests that the ability to cross the bacterium cell membrane is the first step of activity. A discussion in terms of structure-activity relationship is reported.This publication has 3 references indexed in Scilit:
- Acidity Constants of Some Hydroxy-5β-cholan-24-ammonium IonsArchiv der Pharmazie, 1987
- Basic Bile Acids. V. On the Syntheses and Properties of Basic Bile Acids and Their DerivativesBulletin of the Chemical Society of Japan, 1965
- A Protein-Free Medium for Primary Isolation of the Gonococcus and MeningococcusExperimental Biology and Medicine, 1941