Production of Rickettsial Complement-Fixing Antigens in Tissue Culture
Open Access
- 1 April 1968
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 100 (4) , 821-824
- https://doi.org/10.4049/jimmunol.100.4.821
Abstract
Summary: These studies have shown that potent rickettsial complement-fixing antigens can be prepared from BS-C-1 cell cultures infected with R. prowazeki, R. mooseri, and three strains of R. tsutsugamushi. The R. prowazeki and R. mooseri antigens showed type specificity and stability. A broadly reactive R. tsutsugamushi antigen could be prepared by combining the specific antigens of the three strains employed; such a trivalent antigen has potential value in diagnostic serology.Keywords
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