Tyrosinase Immobilized within Artificial Cells for Detoxification in Liver Failure: I. Preparation and in Vitro Studies
- 1 September 1980
- journal article
- research article
- Published by SAGE Publications in The International Journal of Artificial Organs
- Vol. 3 (5) , 287-291
- https://doi.org/10.1177/039139888000300511
Abstract
The in vitro removal of tyrosine by means of perfusion over immobilized tyrosinase within artificial cells was studied. The assayed activity of the microencapsulated tyrosinase was about half the value of the same amount of enzyme in free solution. Further studies were conducted to determine the stability, kinetics, and clearance of this system. The results obtained suggest that immobilized tyrosinase within artificial cells is efficient in removing tyrosine in vitro and further study in an animal model is feasible.Keywords
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