A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-Associated Herpesvirus
- 12 September 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 277 (5332) , 1656-1659
- https://doi.org/10.1126/science.277.5332.1656
Abstract
Kaposi's sarcoma–associated herpesvirus encodes a chemokine called vMIP-II. This protein displayed a broader spectrum of receptor activities than any mammalian chemokine as it bound with high affinity to a number of both CC and CXC chemokine receptors. Binding of vMIP-II, however, was not associated with the normal, rapid mobilization of calcium from intracellular stores; instead, it blocked calcium mobilization induced by endogenous chemokines. In freshly isolated human monocytes the virally encoded vMIP-II acted as a potent and efficient antagonist of chemotaxis induced by chemokines. Because vMIP-II could inhibit cell entry of human immunodeficiency virus (HIV) mediated through CCR3 and CCR5 as well as CXCR4, this protein may serve as a lead for development of broad-spectrum anti-HIV agents.Keywords
This publication has 33 references indexed in Scilit:
- A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion CofactorsCell, 1996
- A Molecular Switch of Chemokine Receptor SelectivityPublished by Elsevier ,1996
- Activation of Dual T Cell Signaling Pathways by the Chemokine RANTESScience, 1995
- Proton NMR Assignments and Solution Conformation of RANTES, a Chemokine of the C-C TypeBiochemistry, 1995
- Mutation of Leu25 and Val27 Introduces CC Chemokine Activity into Interleukin-8Published by Elsevier ,1995
- Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's SarcomaScience, 1994
- Chemokine receptors and molecular mimicryImmunology Today, 1994
- Efficient amidation of C-peptide deleted NPY precursors by non-endocrine cells is affected by the presence of Lys-Arg at the C-terminusMolecular and Cellular Endocrinology, 1993
- Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2Biochemistry, 1991
- Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectorsFEBS Letters, 1990