Rationally Designed Ligands for Asymmetric Iridium-Catalyzed Hydrogenation of Olefins
- 13 October 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (44) , 14308-14309
- https://doi.org/10.1021/ja0464241
Abstract
A new class of chiral N,P-ligands for the Ir-catalyzed asymmetric hydrogenation of aryl alkenes has been developed. These new ligands proved to be highly efficient and tolerates a broad range of substrates. The enantiomeric excesses are in the range of the best ever reported. The results can be rationalized with the proposed selectivity model.Keywords
This publication has 9 references indexed in Scilit:
- π‐Conjugated Oligo‐(p‐phenylenevinylene) Rosettes and Their Tubular Self‐AssemblyAngewandte Chemie International Edition in English, 2003
- An Enantioselective Biomimetic Total Synthesis of (−)‐SiccaninAngewandte Chemie International Edition in English, 2003
- A Highly Practical and Enantioselective Reagent for the Allylation of AldehydesAngewandte Chemie International Edition in English, 2003
- Iridium‐Catalyzed Enantioselective Hydrogenation of OlefinsAdvanced Synthesis & Catalysis, 2003
- Optically Active Iridium Imidazol-2-ylidene-oxazoline Complexes: Preparation and Use in Asymmetric Hydrogenation of ArylalkenesJournal of the American Chemical Society, 2002
- Synthesis and Application of Chiral Phosphino-Imidazoline Ligands: Ir-Catalyzed Enantioselective HydrogenationOrganic Letters, 2002
- A New Class of Modular Phosphinite–Oxazoline Ligands: Ir-Catalyzed Enantioselective Hydrogenation of Alkenes We thank Dr. Martin Studer and Dr. Benoît Pugin (Solvias AG, Basel) for fruitful discussions, and Prof. Kevin Burgess (Texas A&M University) for preprints of related unpublished work. Financial support by the Swiss National Science Foundation is gratefully acknowledged.Angewandte Chemie International Edition in English, 2001
- Enantioselective Hydrogenation of Olefins with Iridium-Phosphanodihydrooxazole CatalystsAngewandte Chemie International Edition in English, 1998
- Iridium compounds in catalysisAccounts of Chemical Research, 1979