EFFECTIVENESS OF 2-ROUTE CHEMOTHERAPY USING CISPLATIN AND ITS ANTIDOTE, SODIUM THIOSULFATE, ON LIFESPAN OF RATS BEARING METASTATIC LIVER-TUMORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 67  (12) , 1067-1074
Abstract
The therapeutic efficacy of 2-route chemotherapy (TRC) using cisplatin (DDP) and its potent antidote, sodium thiosulfate (STS), was studied on rat metastatic liver tumors. Twenty mg/kg of DDP was given to rats via the heptic artery in combination with systemic STS at a dose of 1054 mg/kg (100-fold molar ratio to 20 mg/kg of DDP) or at 2 doses of 1054 mg/kg. As controls, 5 or 4 mg/kg of DDP alone was given intra-arterially (i.a.) or i.v. Antitumor effects were evaluated by prolongation in lifespan after the tumor cell inoculation. Side effects were assessed by weight loss, BUN [blood urea nitrogen], and serum transaminases after the chemotherapy. TRC resulted in the longest life span, with a minimum weight loss and without elevation of BUN or serum transaminases. The therapeutic efficacy of TRC was enhanced by temporary ligation of the portal vein for 5 min, performed simultaneously with DDP infusion. The findings clearly indicate the effectiveness of TRC using i.a. DDP in a high dose and in combination with i.v. STS.