Illuminating the Evolutionary History of Chlamydiae
Top Cited Papers
- 30 April 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5671) , 728-730
- https://doi.org/10.1126/science.1096330
Abstract
Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.Keywords
This publication has 22 references indexed in Scilit:
- ATP/ADP Translocases: a Common Feature of Obligate Intracellular Amoebal Symbionts Related to Chlamydiae and RickettsiaeJournal of Bacteriology, 2004
- Parachlamydia acanthamoebaEnters and Multiplies within Human Macrophages and Induces Their ApoptosisInfection and Immunity, 2003
- Evidence That Plant-Like Genes in Chlamydia Species Reflect an Ancestral Relationship between Chlamydiaceae, Cyanobacteria, and the ChloroplastGenome Research, 2002
- Identification of a Chlamydial Protease–Like Activity Factor Responsible for the Degradation of Host Transcription FactorsThe Journal of Experimental Medicine, 2001
- Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USANucleic Acids Research, 2000
- Phylogenetic Diversity among Geographically Dispersed Chlamydiales Endosymbionts Recovered from Clinical and Environmental Isolates of Acanthamoeba sppApplied and Environmental Microbiology, 2000
- Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39Nucleic Acids Research, 2000
- Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organismsInternational Journal of Systematic and Evolutionary Microbiology, 1999
- Molecular evidence for the existence of additional members of the order ChlamydialesMicrobiology, 1999
- Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatisScience, 1998