Attraction of human monocytes by the neuropeptide secretoneurin
- 8 November 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 334 (1) , 41-44
- https://doi.org/10.1016/0014-5793(93)81676-q
Abstract
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.Keywords
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