SIGNET‐RING CELLS IN ADVANCED GASTRIC CANCER A Clinical, Pathological and Histochemical Study
- 1 July 1987
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Series A :Pathology
- Vol. 95A (1-6) , 225-231
- https://doi.org/10.1111/j.1699-0463.1987.tb00035_95a.x
Abstract
A pathological and histochemical study on the presence of signet‐ring cells (SRC) in 108 advanced gastric cancer (AGC) has been evaluated. According to Laurén's classification, 59 were of intestinal (I) and 49 of diffuse (D) type. The amount of SRC seems to be a prognostic parameter in D‐carcinoma: the 5‐year survival rate was 49% and 22% in cases with 1–24% and 75–100% SRC, respectively. Histochemically, in our series of SRC D‐carcinoma the quality of mucin secretion of SRC closely resembled the goblet cells of intestinal metaplasia. The histogenetic origin of D‐gastric carcinoma was discussed.Keywords
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